Leonardo Sorci : rechercher sur Z-Library

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1

Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD

Leonardo Sorci, Yongping Pan, Yvonne Eyobo, Irina Rodionova, Nian Huang, Oleg Kurnasov, Shijun Zhong, Alexander D. MacKerell Jr., Hong Zhang, Andrei L. Osterman

Journal:

Chemistry & Biology

Année:

2009

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2009

2

Initial-Rate Kinetics of Human NMN-Adenylyltransferases: Substrate and Metal Ion Specificity, Inhibition by Products and Multisubstrate Analogues, and Isozyme Contributions to NAD+ Biosynthesis†

Franchetti, Palmarisa, Orsomando, Giuseppe, Magni, Giulio, Petrelli, Riccardo, Cappellacci, Loredana, Sorci, Leonardo, Cimadamore, Flavio, Scotti, Stefania

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 225 KB

english, 2007

3

Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism

Nian Huang, Leonardo Sorci, Xuejun Zhang, Chad A. Brautigam, Xiaoqing Li, Nadia Raffaelli, Giulio Magni, Nick V. Grishin, Andrei L. Osterman, Hong Zhang

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 2.32 MB

english, 2008

4

Identification of a novel human nicotinamide mononucleotide adenylyltransferase

Nadia Raffaelli, Leonardo Sorci, Adolfo Amici, Monica Emanuelli, Francesca Mazzola, Giulio Magni

Journal:

Biochemical and Biophysical Research Communications

Année:

2002

Langue:

english

Fichier:

PDF, 227 KB

english, 2002

5

S7.6 Glutamate exposure of cortical neurons evokes initial oxidation of NADPH in mitochondria followed by a delayed oxidation of NADH: Delayed redox and calcium deregulation

Akos A. Gerencser, Judit Doczi, Leonardo Sorci, Andrei Osterman, David G. Nicholls, Vera Adam-Vizi

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

2008

Langue:

english

Fichier:

PDF, 74 KB

english, 2008

6

Characterization of bacterial NMN deamidase as a Ser/Lys hydrolase expands diversity of serine amidohydrolases

Sorci, Leonardo, Brunetti, Lucia, Cialabrini, Lucia, Mazzola, Francesca, Kazanov, Marat D., D’Auria, Sabato, Ruggieri, Silverio, Raffaelli, Nadia

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 3.21 MB

english, 2014

7

Characterization of Mycobacterium tuberculosis NAD Kinase: Functional Analysis of the Full-Length Enzyme by Site-Directed Mutagenesis †

Raffaelli, Nadia, Finaurini, Lucia, Mazzola, Francesca, Pucci, Lisa, Sorci, Leonardo, Amici, Adolfo, Magni, Giulio

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 178 KB

english, 2004

8

Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement

Huang, Nian, Kolhatkar, Rohit, Eyobo, Yvonne, Sorci, Leonardo, Rodionova, Irina, Osterman, Andrei L., MacKerell, Alexander D., Zhang, Hong

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 4.45 MB

english, 2010

9

NAD homeostasis in the bacterial response to DNA/RNA damage

Sorci, Leonardo, Ruggieri, Silverio, Raffaelli, Nadia

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 4.75 MB

english, 2014

10

Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues

Ruggieri, Silverio, Orsomando, Giuseppe, Sorci, Leonardo, Raffaelli, Nadia

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2015

Langue:

english

Fichier:

PDF, 927 KB

english, 2015

11

Mycobacterial Nicotinate Mononucleotide Adenylyltransferase

Rodionova, Irina A., Zuccola, Harmon J., Sorci, Leonardo, Aleshin, Alexander E., Kazanov, Marat D., Ma, Chen-Ting, Sergienko, Eduard, Rubin, Eric J., Locher, Christopher P., Osterman, Andrei L.

Journal:

Journal of Biological Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 4.53 MB

english, 2015

12

Comprehensive Natural Products II || Genomics and Enzymology of NAD Biosynthesis

Sorci, Leonardo

Année:

2010

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2010

13

Synthesis and Degradation of Adenosine 5′-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases

Amici, Adolfo, Grolla, Ambra A., Del Grosso, Erika, Bellini, Roberta, Bianchi, Michele, Travelli, Cristina, Garavaglia, Silvia, Sorci, Leonardo, Raffaelli, Nadia, Ruggieri, Silverio, Genazzani, Armand

Journal:

Cell Chemical Biology

Année:

2017

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2017

14

Genomics-Guided Analysis of NAD Recycling Yields Functional Elucidation of COG1058 as a New Family of Pyrophosphatases

Cialabrini, Lucia, Ruggieri, Silverio, Kazanov, Marat D., Sorci, Leonardo, Mazzola, Francesca, Orsomando, Giuseppe, Osterman, Andrei L., Raffaelli, Nadia, Netto, Luis Eduardo Soares

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 2.65 MB

english, 2013

15

Biological Activities of the Essential Oil from Erigeron floribundus

Petrelli, Riccardo, Orsomando, Giuseppe, Sorci, Leonardo, Maggi, Filippo, Ranjbarian, Farahnaz, Biapa Nya, Prosper, Petrelli, Dezemona, Vitali, Luca, Lupidi, Giulio, Quassinti, Luana, Bramucci, Massim

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 250 KB

english, 2016

16

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer

Audrito, Valentina, Managò, Antonella, Gaudino, Federica, Sorci, Leonardo, Messana, Vincenzo Gianluca, Raffaelli, Nadia, Deaglio, Silvia

Journal:

Frontiers in Immunology

Année:

2019

Fichier:

PDF, 2.68 MB

2019

17

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Managò, Antonella, Audrito, Valentina, Mazzola, Francesca, Sorci, Leonardo, Gaudino, Federica, Gizzi, Katiuscia, Vitale, Nicoletta, Incarnato, Danny, Minazzato, Gabriele, Ianniello, Alice, Varriale, A

Journal:

Nature Communications

Année:

2019

Langue:

english

Fichier:

PDF, 3.30 MB

english, 2019

18

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Managò, Antonella, Audrito, Valentina, Mazzola, Francesca, Sorci, Leonardo, Gaudino, Federica, Gizzi, Katiuscia, Vitale, Nicoletta, Incarnato, Danny, Minazzato, Gabriele, Ianniello, Alice, Varriale, A

Journal:

Nature Communications

Année:

2019

Fichier:

PDF, 3.30 MB

2019

19

Functional Characterization of COG1713 (YqeK) as a Novel Diadenosine Tetraphosphate Hydrolase Family

Minazzato, Gabriele, Gasparrini, Massimiliano, Amici, Adolfo, Cianci, Michele, Mazzola, Francesca, Orsomando, Giuseppe, Sorci, Leonardo, Raffaelli, Nadia, Galperin, Michael Y.

Journal:

Journal of Bacteriology

Année:

2020

Fichier:

PDF, 3.31 MB

2020

20

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival

Schultz, Michael D., Dadali, Tulin, Jacques, Sylvain A., Muller-Steffner, HÃ©lÃ¨ne, Foote, Jeremy B., Sorci, Leonardo, Kellenberger, Esther, Botta, Davide, Lund, Frances E., Collins, James J.

Journal:

Année:

2020

Fichier:

PDF, 4.77 MB

2020